MedBugs: SAQ #66

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Case: Valproate toxicity

A 29-year-old woman with a history of epilepsy, presents a er inges ng 90 tablets x 200mg of sodium valproate. She weighs 60kg.

1. Complete the table, describing the dose-related risk assessment for valproate overdose. 4 marks

2. List (4) blood tests you would perform including your rationale. 8 marks

3. List (2) indications for dialysis in valproate poisoning. 2 marks

Sodium valproate is known to be teratogenic.

4. Other than antiepileptics, list (4) teratogenic drugs. 4 marks

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Case: Valproate toxicity

1. Complete the table, describing the dose-related risk assessment for valproate overdose. 4 marks

2. List (4) blood tests you would perform including your rationale. 8 marks

3. List (2) indications for dialysis in valproate poisoning. 2 marks

4. Other than antiepileptics, list (4) teratogenic drugs. 4 marks

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