43-year-old female was found by her husband with a potential deliberate poisoning. She is normally on amitriptyline, venlafaxine XR and pregabalin. On arrival at the Emergency Department, her vitals are:

  • HR 110 bpm
SBP 60 mm Hg.
  • GCS 8

Polypharmacy overdose

1. List 3 abnormalities on this ECG 3 marks

2. List 3 drug classes with 1 example from each class that can cause these ECG changes in overdose 3 marks

3. Outline 6 important and immediate therapeutic interventions (including procedures or pharmacologic treatments) you would use to treat this patient including doses and endpoints where relevant 12 marks