An 18-year-old woman presents following an overdose of paracetamol. Initial concentration is 660 Β΅mol/L.

Paracetamol overdose

1. What is the toxic dose of paracetamol in an adult following an acute ingestion? 1 mark

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2. List two history questions required to interpret this result. 2 marks

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The resident has assessed the patient and has β€œmedically cleared” them and they have been transferred to psychiatry. The psychiatric registrar calls you and is concerned that the patient should have antidote treatment for paracetamol poisoning. She tells you the patient ingested 40 x 500mg paracetamol staggered between 2 am and 6 am. The paracetamol level was taken at 10 am. It is now 4pm.

3. What is your ongoing management? 3 marks

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A 27 y old male ingested 50 x 665mg (33.250g) 3 hours ago.

4. o. State 2 important aspects of his management (include doses) 4 marks

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An adult patient arrives 7h after ingesting 12g of Paracetamol IR.

5. What is the most important aspect their initial management? 1 mark

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